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DIHYDRODIPICOLINATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND PDC

Source organism: Mycobacterium tuberculosis
Biochemical function: NADH binding
Biological process: diaminopimelate biosynthetic process
Cellular component: peptidoglycan-based cell wall

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EC 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase

Reaction catalysed:
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H
Systematic name:
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NADP(+) 4-oxidoreductase
Alternative Name(s):
  • 2,3,4,5-tetrahydrodipicolinate:NAD(P)(+) oxidoreductase
  • DapB (gene name)
  • Dihydrodipicolinate reductase
  • Dihydrodipicolinic acid reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05173
Domain description: Dihydrodipicolinate reductase, C-terminus
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
The deposited structure of PDB entry 1c3v contains 2 copies of Pfam domain PF05173 (Dihydrodipicolinate reductase, C-terminus) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain A.

PF01113
Domain description: Dihydrodipicolinate reductase, N-terminus
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
The deposited structure of PDB entry 1c3v contains 2 copies of Pfam domain PF01113 (Dihydrodipicolinate reductase, N-terminus) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023940
Domain description: Dihydrodipicolinate reductase
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
IPR022664
Domain description: Dihydrodipicolinate reductase, conserved site
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
IPR022663
Domain description: Dihydrodipicolinate reductase, C-terminal
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
IPR000846
Domain description: Dihydrodipicolinate reductase, N-terminal
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
The deposited structure of PDB entry 1c3v contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain A.
3.30.360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dihydrodipicolinate Reductase; domain 2
Homology: Dihydrodipicolinate Reductase; domain 2
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
The deposited structure of PDB entry 1c3v contains 2 copies of CATH domain 3.30.360.10 (Dihydrodipicolinate Reductase; domain 2) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain A.
SCOP SCOP annotations
51800
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
The deposited structure of PDB entry 1c3v contains 2 copies of SCOP domain 51800 (Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain A.
55368
Class: Alpha and beta proteins (a+b)
Fold: FwdE/GAPDH domain-like
Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate reductase
The deposited structure of PDB entry 1c3v contains 2 copies of SCOP domain 55368 (Dihydrodipicolinate reductase-like) in 4-hydroxy-tetrahydrodipicolinate reductase. Showing 1 copy in chain A.

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