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HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: extracellular matrix

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EC 3.4.24.17: Stromelysin 1

Reaction catalysed:
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
Alternative Name(s):
  • Collagen-activating protein
  • Collagenase activating protein
  • MMP-3
  • Matrix metalloproteinase 3
  • Neutral proteoglycanase
  • Procollagenase activator
  • Proteoglycanase
  • Stromelysin
  • Transin

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1c8t contains 2 copies of Pfam domain PF00413 (Matrixin) in Stromelysin-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Stromelysin-1
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Stromelysin-1
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Stromelysin-1
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Stromelysin-1
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Stromelysin-1

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1c8t contains 2 copies of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Stromelysin-1. Showing 1 copy in chain A.
SCOP SCOP annotation
55528
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1c8t contains 2 copies of SCOP domain 55528 (Matrix metalloproteases, catalytic domain) in Stromelysin-1. Showing 1 copy in chain A.

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