› 1cdy

X-ray diffraction
2Å resolution

STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH GLY 47 REPLACED BY SER

Released:
DOI: 10.2210/pdb1cdy/pdb
PDB entry 1cdy coloured by chain, front view.
PDB entry 1cdy coloured by chain, side view.
PDB entry 1cdy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.
Wu H, Myszka DG, Tendian SW, Brouillette CG, Sweet RW, Chaiken IM, Hendrickson WA
Proc Natl Acad Sci U S A 93 15030-5 (1996)
PMID: 8986758

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface glycoprotein CD4 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.76 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01730 (Residues: 26-203; Coverage: 41%)
Gene name: CD4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 82.2Å b: 29.9Å c: 85.5Å
α: 90° β: 115.3° γ: 90°
R-values:
R R work R free
0.202 0.202 not available
Expression system: Cricetulus griseus

Quick links

Citations

8 review citations

Flavonoids: promising natural compounds against viral infections.
Zakaryan et al. (2017)
7 more

9 mentions without citation

Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey.
Pancer et al. (2004)
8 more