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THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)

Source organisms:
Biochemical function: protein binding
Biological process: regulation of store-operated calcium entry
Cellular component: extracellular region

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EC 3.4.21.1: Chymotrypsin

Reaction catalysed:
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
Systematic name:
-
Alternative Name(s):
  • Alpha-chymar
  • Alpha-chymar ophth
  • Alpha-chymotrypsin
  • Alpha-chymotrypsin A
  • Avazyme
  • Chymar
  • Chymotest
  • Chymotrypsin A
  • Chymotrypsin B
  • Chymotrypsins A and B
  • Enzeon
  • Quimar
  • Quimotrase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00050
Domain description: Kazal-type serine protease inhibitor domain
Occurring in:
  1. Serine protease inhibitor Kazal-type 1
The deposited structure of PDB entry 1cgj contains 1 copy of Pfam domain PF00050 (Kazal-type serine protease inhibitor domain) in Serine protease inhibitor Kazal-type 1. Showing 1 copy in chain B [auth I].

PF00089
Domain description: Trypsin
Occurring in:
  1. Chymotrypsinogen A
The deposited structure of PDB entry 1cgj contains 1 copy of Pfam domain PF00089 (Trypsin) in Chymotrypsinogen A. Showing 1 copy in chain A [auth E].

InterPro InterPro annotations
IPR002350
Domain description: Kazal domain
Occurring in:
  1. Serine protease inhibitor Kazal-type 1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Chymotrypsinogen A
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Chymotrypsinogen A
IPR001239
Domain description: Proteinase inhibitor I1, Kazal-type, metazoa
Occurring in:
  1. Serine protease inhibitor Kazal-type 1
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Chymotrypsinogen A
IPR036058
Domain description: Kazal domain superfamily
Occurring in:
  1. Serine protease inhibitor Kazal-type 1
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Chymotrypsinogen A
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Chymotrypsinogen A
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Chymotrypsinogen A

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsinogen A
The deposited structure of PDB entry 1cgj contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Chymotrypsinogen A. Showing 2 copies in chain A [auth E].
3.30.60.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Serine protease inhibitor Kazal-type 1
The deposited structure of PDB entry 1cgj contains 1 copy of CATH domain 3.30.60.30 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Serine protease inhibitor Kazal-type 1. Showing 1 copy in chain B [auth I].
SCOP SCOP annotations
57468
Class: Small proteins
Fold: Kazal-type serine protease inhibitors
Superfamily: Kazal-type serine protease inhibitors
Occurring in:
  1. Serine protease inhibitor Kazal-type 1
The deposited structure of PDB entry 1cgj contains 1 copy of SCOP domain 57468 (Ovomucoid domain III-like) in Serine protease inhibitor Kazal-type 1. Showing 1 copy in chain B [auth I].
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsinogen A
The deposited structure of PDB entry 1cgj contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Chymotrypsinogen A. Showing 1 copy in chain A [auth E].

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