› 1ck4

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF RAT A1B1 INTEGRIN I-DOMAIN.

Released:
DOI: 10.2210/pdb1ck4/pdb
PDB entry 1ck4 coloured by chain, front view.
PDB entry 1ck4 coloured by chain, side view.
PDB entry 1ck4 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function.
Nolte M, Pepinsky RB, Koteliansky V, Gotwals PJ, Karpusas M
FEBS Lett 452 379-85 (1999)
PMID: 10386626

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-538963 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 198 amino acids
Theoretical weight: 22.12 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18614 (Residues: 167-364; Coverage: 17%)
Gene name: Itga1
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 34.77Å b: 85.92Å c: 132.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.234 0.299
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.
Whittaker et al. (2002)
9 more

2 mentions without citation

Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.
Weinreb et al. (2012)
1 more