EC 3.1.21.4: Type II site-specific deoxyribonuclease
Reaction catalysed:
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates
Systematic name:
-
Alternative Name(s):
- Type II restriction enzyme
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence family
Protein family (Pfam)
![The deposited structure of PDB entry 1cl8 contains 1 copy of Pfam domain PF02963 (Restriction endonuclease EcoRI) in Type II restriction enzyme EcoRI. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1cl8_2_A_Pfam_PF02963_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1cl8</span> contains 1 copy of Pfam domain <span class='highlight'>PF02963 (Restriction endonuclease EcoRI)</span> in <span class='highlight'>Type II restriction enzyme EcoRI</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotations
IPR018131
Domain description:
Restriction endonuclease, type II, EcoRI, Proteobacteria
Occurring in:
Occurring in:
CATH domain![The deposited structure of PDB entry 1cl8 contains 1 copy of CATH domain 3.40.580.10 (ECO RI Endonuclease; Chain A) in Type II restriction enzyme EcoRI. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1cl8_2_A_CATH_3.40.580.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1cl8</span> contains 1 copy of CATH domain <span class='highlight'>3.40.580.10 (ECO RI Endonuclease; Chain A)</span> in <span class='highlight'>Type II restriction enzyme EcoRI</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
SCOP annotation![The deposited structure of PDB entry 1cl8 contains 1 copy of SCOP domain 52981 (Restriction endonuclease EcoRI) in Type II restriction enzyme EcoRI. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1cl8_2_A_SCOP_52981_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1cl8</span> contains 1 copy of SCOP domain <span class='highlight'>52981 (Restriction endonuclease EcoRI)</span> in <span class='highlight'>Type II restriction enzyme EcoRI</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")