› 1cqa

X-ray diffraction
2.4Å resolution

BIRCH POLLEN PROFILIN

Released:
DOI: 10.2210/pdb1cqa/pdb
PDB entry 1cqa coloured by chain, front view.
PDB entry 1cqa coloured by chain, side view.
PDB entry 1cqa coloured by chain, top view.
Source organism: Betula pendula
Primary publication:
The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin.
Fedorov AA, Ball T, Mahoney NM, Valenta R, Almo SC
Structure 5 33-45 (1997)
PMID: 9016715

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150596 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Profilin-1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.29 KDa
Source organism: Betula pendula
Expression system: Escherichia coli
UniProt:
  • Canonical: P25816 (Residues: 1-133; Coverage: 100%)
Gene name: BETVII
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 59.9Å b: 59.9Å c: 85.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 not available
Expression system: Escherichia coli

Quick links

Citations

37 review citations

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen).
Bousquet et al. (2008)
36 more

14 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
13 more