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CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR

Source organism: Homo sapiens
Biochemical function: transferrin receptor activity
Biological process: transferrin transport
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF04253
Domain description: Transferrin receptor-like dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of Pfam domain PF04253 (Transferrin receptor-like dimerisation domain) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.

PF04389
Domain description: Peptidase family M28
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of Pfam domain PF04389 (Peptidase family M28) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.

PF02225
Domain description: PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of Pfam domain PF02225 (PA domain) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036757
Domain description: Transferrin receptor-like, dimerisation domain superfamily
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR007365
Domain description: Transferrin receptor-like, dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR007484
Domain description: Peptidase M28
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR003137
Domain description: PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR037324
Domain description: Transferrin receptor protein 1/2, PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR046450
Domain description: PA domain superfamily
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR039373
Domain description: Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Occurring in:
  1. Transferrin receptor protein 1, serum form

Structure domains

CATH CATH domains
3.40.630.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Zn peptidases
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of CATH domain 3.40.630.10 (Aminopeptidase) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.
1.20.930.40
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transcription Elongation Factor S-II; Chain A
Homology: Transferrin receptor-like, dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of CATH domain 1.20.930.40 (Transcription Elongation Factor S-II; Chain A) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.
3.50.30.30
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Glucose Oxidase; domain 1
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of CATH domain 3.50.30.30 (Glucose Oxidase; domain 1) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.
SCOP SCOP annotations
53210
Class: Alpha and beta proteins (a/b)
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of SCOP domain 53210 (FolH catalytic domain-like) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.
47673
Class: All alpha proteins
Fold: N-cbl like
Superfamily: Transferrin receptor-like dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of SCOP domain 47673 (Transferrin receptor-like dimerisation domain) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.
52026
Class: Alpha and beta proteins (a/b)
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 1cx8 contains 8 copies of SCOP domain 52026 (PA domain) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain A.

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