Function and Biology

CRYSTAL STRUCTURE OF CYANIDE-BOUND HUMAN MYELOPEROXIDASE ISOFORM C AT PH 5.5

Source organism: Homo sapiens
Biochemical function: heme binding
Biological process: response to oxidative stress
Cellular component: not assigned

EC 1.11.2.2: Myeloperoxidase

Reaction catalysed:
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
Systematic name:
Chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)
Alternative Name(s):
  • MPO
  • Verdoperoxidase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03098
Domain description: Animal haem peroxidase
Occurring in:
  1. Myeloperoxidase heavy chain
The deposited structure of PDB entry 1d5l contains 2 copies of Pfam domain PF03098 (Animal haem peroxidase) in Myeloperoxidase heavy chain. Showing 1 copy in chain B [auth C].

InterPro InterPro annotations
IPR019791
Domain description: Haem peroxidase, animal-type
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain
IPR037120
Domain description: Haem peroxidase domain superfamily, animal type
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain

Structure domain

CATH CATH domain
1.10.640.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Myeloperoxidase, subunit C
Homology: Haem peroxidase domain superfamily, animal type
Occurring in:
  1. Myeloperoxidase heavy chain
The deposited structure of PDB entry 1d5l contains 2 copies of CATH domain 1.10.640.10 (Myeloperoxidase, subunit C) in Myeloperoxidase heavy chain. Showing 1 copy in chain B [auth C].
SCOP SCOP annotation
48132
Class: All alpha proteins
Fold: Heme-dependent peroxidases
Superfamily: Heme-dependent peroxidases
Occurring in:
  1. Myeloperoxidase light chain
  2. Myeloperoxidase heavy chain
The deposited structure of PDB entry 1d5l contains 2 copies of SCOP domain 48132 (Myeloperoxidase-like) in Myeloperoxidase light chain. Showing 1 copy in chain A.