Function and Biology

DIPHTHERIA TOX REPRESSOR (C102D MUTANT)/TOX DNA OPERATOR COMPLEX

Source organism: Corynebacterium diphtheriae
Biochemical function: protein dimerization activity
Biological process: negative regulation of DNA-templated transcription
Cellular component: cytoplasm

Sequence families

Pfam Protein families (Pfam)
PF18357
Domain description: Diphteria toxin repressor SH3 domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of Pfam domain PF18357 (Diphteria toxin repressor SH3 domain) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A] (this domain is out of the observed residue ranges!).

PF02742
Domain description: Iron dependent repressor, metal binding and dimerisation domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of Pfam domain PF02742 (Iron dependent repressor, metal binding and dimerisation domain) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A].

PF01325
Domain description: Iron dependent repressor, N-terminal DNA binding domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of Pfam domain PF01325 (Iron dependent repressor, N-terminal DNA binding domain) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR036421
Domain description: Iron dependent repressor, metal binding and dimerisation domain superfamily
Occurring in:
  1. Diphtheria toxin repressor
IPR022687
Domain description: DTXR-type HTH domain
Occurring in:
  1. Diphtheria toxin repressor
IPR038157
Domain description: Ferrous iron transporter, core domain
Occurring in:
  1. Diphtheria toxin repressor
IPR040767
Domain description: Diphteria toxin repressor/Iron-dependent repressor IdeR, SH3 domain
Occurring in:
  1. Diphtheria toxin repressor
IPR008988
Domain description: Transcriptional repressor, C-terminal
Occurring in:
  1. Diphtheria toxin repressor
IPR001367
Domain description: Iron dependent repressor, metal binding and dimerisation domain
Occurring in:
  1. Diphtheria toxin repressor
IPR022689
Domain description: Iron dependent repressor
Occurring in:
  1. Diphtheria toxin repressor
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Diphtheria toxin repressor
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Diphtheria toxin repressor

Structure domains

CATH CATH domains
1.10.60.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Diphtheria Toxin Repressor; domain 2
Homology: Iron dependent repressor, metal binding and dimerisation domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of CATH domain 1.10.60.10 (Diphtheria Toxin Repressor; domain 2) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A].
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A].
SCOP SCOP annotations
47980
Class: All alpha proteins
Fold: Iron-dependent repressor protein, dimerization domain
Superfamily: Iron-dependent repressor protein, dimerization domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of SCOP domain 47980 (Iron-dependent repressor protein, dimerization domain) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A].
46882
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. Diphtheria toxin repressor
The deposited structure of PDB entry 1ddn contains 4 copies of SCOP domain 46882 (Iron-dependent repressor protein) in Diphtheria toxin repressor. Showing 1 copy in chain C [auth A].