› 1df4

X-ray diffraction
1.45Å resolution

INTERACTIONS BETWEEN HIV-1 GP41 CORE AND DETERGENTS AND THEIR IMPLICATIONS FOR MEMBRANE FUSION

Released:
DOI: 10.2210/pdb1df4/pdb
PDB entry 1df4 coloured by chain, front view.
PDB entry 1df4 coloured by chain, side view.
PDB entry 1df4 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Interactions between HIV-1 gp41 core and detergents and their implications for membrane fusion.
Shu W, Ji H, Lu M
J Biol Chem 275 1839-45 (2000)
PMID: 10636883

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.88 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-655; Coverage: 8%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: R3
Unit cell:
a: 52.383Å b: 52.383Å c: 60.982Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.2 0.245
Expression system: Escherichia coli

Quick links

Citations

22 citation in other articles

The caveolin-1 binding domain of HIV-1 glycoprotein gp41 is an efficient B cell epitope vaccine candidate against virus infection.
Hovanessian et al. (2004)
21 more

9 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
8 more