› 1dg6

X-ray diffraction
1.3Å resolution

CRYSTAL STRUCTURE OF APO2L/TRAIL

Released:
DOI: 10.2210/pdb1dg6/pdb
PDB entry 1dg6 coloured by chain, front view.
PDB entry 1dg6 coloured by chain, side view.
PDB entry 1dg6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Hymowitz SG, O'Connell MP, Ultsch MH, Hurst A, Totpal K, Ashkenazi A, de Vos AM, Kelley RF
Biochemistry 39 633-40 (2000)
PMID: 10651627

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 10 Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 22.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50591 (Residues: 91-281; Coverage: 68%)
Gene names: APO2L, TNFSF10, TRAIL
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R32
Unit cell:
a: 66.435Å b: 66.435Å c: 197.727Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.141 0.141 0.197
Expression system: Escherichia coli

Quick links

Citations

50 review citations

Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Ashkenazi A. (2002)
49 more

14 mentions without citation

Zinc-binding cysteines: diverse functions and structural motifs.
Pace et al. (2014)
13 more