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CRYSTAL STRUCTURE OF LUMAZINE SYNTHASE FROM BRUCELLA ABORTUS

Source organism: Brucella abortus
Biochemical function: transferase activity
Biological process: riboflavin biosynthetic process
Cellular component: riboflavin synthase complex

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EC 2.5.1.78: 6,7-dimethyl-8-ribityllumazine synthase

Reaction catalysed:
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H(2)O + phosphate
Systematic name:
5-amino-6-(D-ribitylamino)uracil butanedionetransferase
Alternative Name(s):
  • 6,7-dimethyl-8-ribityllumazine synthase 1
  • 6,7-dimethyl-8-ribityllumazine synthase 2
  • Lumazine synthase
  • Lumazine synthase 1
  • Lumazine synthase 2
  • MJ0303
  • MbtLS
  • PblS
  • RIB4
  • RibH
  • RibH1
  • RibH1 protein
  • RibH2
  • RibH2 protein
  • Type I lumazine synthase
  • Type II lumazine synthase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00885
Domain description: 6,7-dimethyl-8-ribityllumazine synthase
Occurring in:
  1. 6,7-dimethyl-8-ribityllumazine synthase 2
The deposited structure of PDB entry 1di0 contains 5 copies of Pfam domain PF00885 (6,7-dimethyl-8-ribityllumazine synthase) in 6,7-dimethyl-8-ribityllumazine synthase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR034964
Domain description: Lumazine synthase
Occurring in:
  1. 6,7-dimethyl-8-ribityllumazine synthase 2
IPR036467
Domain description: Lumazine/riboflavin synthase superfamily
Occurring in:
  1. 6,7-dimethyl-8-ribityllumazine synthase 2
IPR002180
Domain description: Lumazine/riboflavin synthase
Occurring in:
  1. 6,7-dimethyl-8-ribityllumazine synthase 2

Structure domain

CATH CATH domain
3.40.50.960
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Lumazine/riboflavin synthase
Occurring in:
  1. 6,7-dimethyl-8-ribityllumazine synthase 2
The deposited structure of PDB entry 1di0 contains 5 copies of CATH domain 3.40.50.960 (Rossmann fold) in 6,7-dimethyl-8-ribityllumazine synthase 2. Showing 1 copy in chain A.
SCOP SCOP annotation
52122
Class: Alpha and beta proteins (a/b)
Fold: Lumazine synthase
Superfamily: Lumazine synthase
Occurring in:
  1. 6,7-dimethyl-8-ribityllumazine synthase 2
The deposited structure of PDB entry 1di0 contains 5 copies of SCOP domain 52122 (Lumazine synthase) in 6,7-dimethyl-8-ribityllumazine synthase 2. Showing 1 copy in chain A.

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