› 1dqr

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF RABBIT PHOSPHOGLUCOSE ISOMERASE, A GLYCOLYTIC ENZYME THAT MOONLIGHTS AS NEUROLEUKIN, AUTOCRINE MOTILITY FACTOR, AND DIFFERENTIATION MEDIATOR

Released:
DOI: 10.2210/pdb1dqr/pdb
PDB entry 1dqr coloured by chain, front view.
PDB entry 1dqr coloured by chain, side view.
PDB entry 1dqr coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator.
Jeffery CJ, Bahnson BJ, Chien W, Ringe D, Petsko GA
Biochemistry 39 955-64 (2000)
PMID: 10653639

Function and Biology Details

Reaction catalysed: 
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucose-6-phosphate isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 557 amino acids
Theoretical weight: 62.7 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: Q9N1E2 (Residues: 2-558; Coverage: 100%)
Gene name: GPI
Sequence domains: Phosphoglucose isomerase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 6PG 2 x 6PG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: C2221
Unit cell:
a: 82.695Å b: 115.272Å c: 271.841Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.212 0.265

Quick links

Citations

14 review citations

Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation.
Bräsen et al. (2014)
13 more

4 mentions without citation

The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonohydroxamic acid.
Arsenieva et al. (2002)
3 more