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Solution structure of the DNA binding domain of the human Forkhead transcription factor AFX (FOXO4)

Source organism: Homo sapiens
Biochemical function: sequence-specific DNA binding
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00250
Domain description: Forkhead domain
Occurring in:
  1. Forkhead box protein O4
The deposited structure of PDB entry 1e17 contains 1 copy of Pfam domain PF00250 (Forkhead domain) in Forkhead box protein O4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001766
Domain description: Fork head domain
Occurring in:
  1. Forkhead box protein O4
IPR030456
Domain description: Fork head domain conserved site 2
Occurring in:
  1. Forkhead box protein O4
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Forkhead box protein O4
IPR047409
Domain description: Forkhead box protein O4, forkhead domain
Occurring in:
  1. Forkhead box protein O4
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Forkhead box protein O4

Structure domain

CATH CATH domain
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Forkhead box protein O4
The deposited structure of PDB entry 1e17 contains 1 copy of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Forkhead box protein O4. Showing 1 copy in chain A.
SCOP SCOP annotation
46832
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. Forkhead box protein O4
The deposited structure of PDB entry 1e17 contains 1 copy of SCOP domain 46832 (Forkhead DNA-binding domain) in Forkhead box protein O4. Showing 1 copy in chain A.

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