› 1e7a

X-ray diffraction
2.2Å resolution

Crystal structure of human serum albumin complexed with the general anesthetic propofol

Released:
DOI: 10.2210/pdb1e7a/pdb
PDB entry 1e7a coloured by chain, front view.
PDB entry 1e7a coloured by chain, side view.
PDB entry 1e7a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures.
Bhattacharya AA, Curry S, Franks NP
J Biol Chem 275 38731-8 (2000)
PMID: 10940303

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand PFL 4 x PFL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P1
Unit cell:
a: 55.4Å b: 55.61Å c: 120.5Å
α: 81.11° β: 90.57° γ: 65.5°
R-values:
R R work R free
0.248 0.248 0.272
Expression system: Saccharomyces cerevisiae

Quick links

Citations

32 review citations

The Halogen Bond.
Cavallo et al. (2016)
31 more

22 mentions without citation

Modeling kinetics of subcellular disposition of chemicals.
Balaz S. (2009)
21 more