› 1e9j

Solution NMR

SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [INCLUDING A SINGLE GLCNAC RESIDUE AT ASN52 AND ASN78]

Released:
DOI: 10.2210/pdb1e9j/pdb
PDB entry 1e9j coloured by chain, ensemble of 26 models, front view.
PDB entry 1e9j coloured by chain, ensemble of 26 models, side view.
PDB entry 1e9j coloured by chain, ensemble of 26 models, top view.
Source organism: Homo sapiens
Primary publication:
Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin.
Erbel PJ, Karimi-Nejad Y, van Kuik JA, Boelens R, Kamerling JP, Vliegenthart JF
Biochemistry 39 6012-21 (2000)
PMID: 10821673

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein hormones alpha chain Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
Sequence domains: Glycoprotein hormone
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DG/SA

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Citations

7 review citations

Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.
Szkudlinski et al. (2002)
6 more

2 mentions without citation

A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer.
Cao et al. (2022)
1 more