EC 6.1.1.20: Phenylalanine--tRNA ligase
Reaction catalysed:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
Systematic name:
L-phenylalanine:tRNA(Phe) ligase (AMP-forming)
Alternative Name(s):
- L-phenylalanyl-tRNA synthetase
- Phenylalanine translase
- Phenylalanine-tRNA synthetase
- Phenylalanyl-tRNA ligase
- Phenylalanyl-tRNA synthetase
- Phenylalanyl-transfer RNA ligase
- Phenylalanyl-transfer RNA synthetase
- Phenylalanyl-transfer ribonucleate synthetase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
RNA family (Rfam)
InterPro annotations
IPR045864
Domain description:
Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
Occurring in:
IPR004532
Domain description:
Phenylalanine-tRNA ligase, class IIc, beta subunit, bacterial type
Occurring in:
Occurring in:
IPR010978
Domain description:
Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
Occurring in:
Occurring in:
Structure domains
CATH domains
3.30.56.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Phenylalanyl-tRNA Synthetase; Chain B, domain 1
Homology:
Phenylalanyl-tRNA Synthetase; Chain B, domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 2 copies of CATH domain <span class='highlight'>3.30.56.10 (Phenylalanyl-tRNA Synthetase; Chain B, domain 1)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 2 copies in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 2 copies of CATH domain 3.30.56.10 (Phenylalanyl-tRNA Synthetase; Chain B, domain 1) in Phenylalanine--tRNA ligase beta subunit. Showing 2 copies in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_CATH_3.30.56.10_image-200x200.png)
3.30.930.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
BirA Bifunctional Protein; domain 2
Homology:
Bira Bifunctional Protein; Domain 2
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of CATH domain <span class='highlight'>3.30.930.10 (BirA Bifunctional Protein; domain 2)</span> in <span class='highlight'>Phenylalanine--tRNA ligase alpha subunit</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in Phenylalanine--tRNA ligase alpha subunit. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_2_A_CATH_3.30.930.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of CATH domain <span class='highlight'>3.30.930.10 (BirA Bifunctional Protein; domain 2)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_CATH_3.30.930.10_image-200x200.png)
3.30.70.380
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Alpha-Beta Plaits
Homology:
Ferrodoxin-fold anticodon-binding domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of CATH domain <span class='highlight'>3.30.70.380 (Alpha-Beta Plaits)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of CATH domain 3.30.70.380 (Alpha-Beta Plaits) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_CATH_3.30.70.380_image-200x200.png)
3.50.40.10
Class:
Alpha Beta
Architecture:
3-Layer(bba) Sandwich
Topology:
Phenylalanyl-tRNA Synthetase; Chain B, domain 3
Homology:
Phenylalanyl-trna Synthetase, Chain B, domain 3
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of CATH domain <span class='highlight'>3.50.40.10 (Phenylalanyl-tRNA Synthetase; Chain B, domain 3)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of CATH domain 3.50.40.10 (Phenylalanyl-tRNA Synthetase; Chain B, domain 3) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_CATH_3.50.40.10_image-200x200.png)
SCOP annotations
46956
Class:
All alpha proteins
Fold:
Putative DNA-binding domain
Superfamily:
Putative DNA-binding domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 2 copies of SCOP domain <span class='highlight'>46956 (Domains B1 and B5 of PheRS-beta, PheT)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 2 copies in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 2 copies of SCOP domain 46956 (Domains B1 and B5 of PheRS-beta, PheT) in Phenylalanine--tRNA ligase beta subunit. Showing 2 copies in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_SCOP_46956_image-200x200.png)
55682
Class:
Alpha and beta proteins (a+b)
Fold:
Class II aaRS and biotin synthetases
Superfamily:
Class II aaRS and biotin synthetases
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of SCOP domain <span class='highlight'>55682 (Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain)</span> in <span class='highlight'>Phenylalanine--tRNA ligase alpha subunit</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of SCOP domain 55682 (Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain) in Phenylalanine--tRNA ligase alpha subunit. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_2_A_SCOP_55682_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of SCOP domain <span class='highlight'>55682 (Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of SCOP domain 55682 (Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_SCOP_55682_image-200x200.png)
54992
Class:
Alpha and beta proteins (a+b)
Fold:
Ferredoxin-like
Superfamily:
Anticodon-binding domain of PheRS
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of SCOP domain <span class='highlight'>54992 (Anticodon-binding domain of PheRS)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of SCOP domain 54992 (Anticodon-binding domain of PheRS) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_SCOP_54992_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of SCOP domain <span class='highlight'>56038 (B3/B4 domain of PheRS, PheT)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of SCOP domain 56038 (B3/B4 domain of PheRS, PheT) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_SCOP_56038_image-200x200.png)
50277
Class:
All beta proteins
Fold:
OB-fold
Superfamily:
Nucleic acid-binding proteins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of SCOP domain <span class='highlight'>50277 (Myf domain)</span> in <span class='highlight'>Phenylalanine--tRNA ligase beta subunit</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of SCOP domain 50277 (Myf domain) in Phenylalanine--tRNA ligase beta subunit. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_3_B_SCOP_50277_image-200x200.png)
46593
Class:
All alpha proteins
Fold:
Long alpha-hairpin
Superfamily:
tRNA-binding arm
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1eiy</span> contains 1 copy of SCOP domain <span class='highlight'>46593 (Phenylalanyl-tRNA synthetase (PheRS))</span> in <span class='highlight'>Phenylalanine--tRNA ligase alpha subunit</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>. The deposited structure of PDB entry 1eiy contains 1 copy of SCOP domain 46593 (Phenylalanyl-tRNA synthetase (PheRS)) in Phenylalanine--tRNA ligase alpha subunit. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/1eiy_2_A_SCOP_46593_image-200x200.png)