› 1f0t

X-ray diffraction
1.8Å resolution

BOVINE TRYPSIN COMPLEXED WITH RPR131247

Released:
DOI: 10.2210/pdb1f0t/pdb
PDB entry 1f0t coloured by chain, front view.
PDB entry 1f0t coloured by chain, side view.
PDB entry 1f0t coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structures of human factor Xa complexed with potent inhibitors.
Maignan S, Guilloteau JP, Pouzieux S, Choi-Sledeski YM, Becker MR, Klein SI, Ewing WR, Pauls HW, Spada AP, Mikol V
J Med Chem 43 3226-32 (2000)
PMID: 10966741

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease 1 Chain: A
Molecule details ›
Chain: A
Length: 243 amino acids
Theoretical weight: 25.44 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 4-246; Coverage: 100%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand SO4 2 x SO4
Ligand PR1 1 x PR1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P212121
Unit cell:
a: 63.44Å b: 63.83Å c: 69.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.179 not available

Quick links

Citations

63 citation in other articles

Role of the active-site solvent in the thermodynamics of factor Xa ligand binding.
Abel et al. (2008)
62 more

6 mentions without citation

Sanjeevini: a freely accessible web-server for target directed lead molecule discovery.
Jayaram et al. (2012)
5 more