EC 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase
Reaction catalysed:
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
Systematic name:
(S)-3-hydroxyacyl-CoA:NAD(+) oxidoreductase
Alternative Name(s):
- 1-specific DPN-linked beta-hydroxybutyric dehydrogenase
- 3-L-hydroxyacyl-CoA dehydrogenase
- 3-beta-hydroxyacyl coenzyme A dehydrogenase
- 3-hydroxyacetyl-coenzyme A dehydrogenase
- 3-hydroxyacyl coenzyme A dehydrogenase
- 3-hydroxybutyryl-CoA dehydrogenase
- 3-hydroxyisobutyryl-CoA dehydrogenase
- 3-keto reductase
- Beta-hydroxy acid dehydrogenase
- Beta-hydroxyacyl CoA dehydrogenase
- Beta-hydroxyacyl dehydrogenase
- Beta-hydroxyacyl-coenzyme A synthetase
- Beta-hydroxyacylcoenzyme A dehydrogenase
- Beta-hydroxybutyrylcoenzyme A dehydrogenase
- Beta-keto-reductase
- Beta-ketoacyl-CoA reductase
- L-3-hydroxyacyl CoA dehydrogenase
- L-3-hydroxyacyl coenzyme A dehydrogenase
GO terms
Biochemical function:
Biological process:
- positive regulation of cold-induced thermogenesis
- regulation of insulin secretion
- negative regulation of insulin secretion
- response to insulin
- cell differentiation
- response to activity
- response to hormone
- response to xenobiotic stimulus
- spermatogenesis
- fatty acid beta-oxidation
- fatty acid metabolic process
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR008927
Domain description:
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.1040.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homology:
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1f14</span> contains 2 copies of CATH domain <span class='highlight'>1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2)</span> in <span class='highlight'>Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1f14 contains 2 copies of CATH domain 1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1f14_1_A_CATH_1.10.1040.10_image-200x200.png)
SCOP annotations
48187
Class:
All alpha proteins
Fold:
6-phosphogluconate dehydrogenase C-terminal domain-like
Superfamily:
6-phosphogluconate dehydrogenase C-terminal domain-like
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1f14</span> contains 2 copies of SCOP domain <span class='highlight'>48187 (HCDH C-domain-like)</span> in <span class='highlight'>Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1f14 contains 2 copies of SCOP domain 48187 (HCDH C-domain-like) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1f14_1_A_SCOP_48187_image-200x200.png)
51868
Class:
Alpha and beta proteins (a/b)
Fold:
NAD(P)-binding Rossmann-fold domains
Superfamily:
NAD(P)-binding Rossmann-fold domains
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1f14</span> contains 2 copies of SCOP domain <span class='highlight'>51868 (6-phosphogluconate dehydrogenase-like, N-terminal domain)</span> in <span class='highlight'>Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1f14 contains 2 copies of SCOP domain 51868 (6-phosphogluconate dehydrogenase-like, N-terminal domain) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1f14_1_A_SCOP_51868_image-200x200.png)