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RAT TRYPSINOGEN MUTANT COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR

X-ray diffraction
1.65Å resolution
PDB entry 1f5r coloured by chain, front view.
PDB entry 1f5r coloured by chain, side view.
PDB entry 1f5r coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pancreatic trypsin inhibitor and Anionic trypsin-2
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Multimeric state: hetero dimer
Accessible surface area: 11905.41 Å2
Buried surface area: 1456.57 Å2
Dissociation area: 685.72 Å2
Dissociation energy (ΔGdiss): 3.37 kcal/mol
Dissociation entropy (TΔSdiss): 10.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133397

Macromolecules

Anionic trypsin-2
Chain: A
Length: 231 amino acids
Theoretical weight: 24.74 KDa
Source organism: Rattus norvegicus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P00763 (Residues: 15-246; Coverage: 99%)
Gene names: Prss2, Try2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Anionic trypsin-2 in PDB entry 1f5r, assembly 1, front view.
Anionic trypsin-2 in PDB entry 1f5r, assembly 1, side view.
Anionic trypsin-2 in PDB entry 1f5r, assembly 1, top view.
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Pancreatic trypsin inhibitor
Chain: I
Length: 65 amino acids
Theoretical weight: 7.34 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00974 (Residues: 36-100; Coverage: 82%)
Pfam: Kunitz/Bovine pancreatic trypsin inhibitor domain
InterPro:
CATH: Pancreatic trypsin inhibitor Kunitz domain
SCOP: Small Kunitz-type inhibitors & BPTI-like toxins
Pancreatic trypsin inhibitor in PDB entry 1f5r, assembly 1, front view.
Pancreatic trypsin inhibitor in PDB entry 1f5r, assembly 1, side view.
Pancreatic trypsin inhibitor in PDB entry 1f5r, assembly 1, top view.
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