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CRYSTAL STRUCTURE ANALYSIS OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE COMPLEXED WITH 5-METHYL-2'-DEOXYPSEUDOURIDINE

Source organism: Lactobacillus leichmannii
Biochemical function: nucleoside deoxyribosyltransferase activity
Biological process: nucleotide salvage
Cellular component: not assigned

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EC 2.4.2.6: Nucleoside deoxyribosyltransferase

Reaction catalysed:
2-deoxy-D-ribosyl-base(1) + base(2) = 2-deoxy-D-ribosyl-base(2) + base(1)
Systematic name:
Nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase
Alternative Name(s):
  • Deoxyribose transferase
  • Nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)
  • Nucleoside deoxyribosyltransferase II (purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase)
  • Nucleoside trans-N-deoxyribosylase
  • Purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase
  • Trans-N-deoxyribosylase
  • Trans-N-glycosidase
  • Trans-deoxyribosylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF05014
Domain description: Nucleoside 2-deoxyribosyltransferase
Occurring in:
  1. Nucleoside deoxyribosyltransferase
The deposited structure of PDB entry 1f8y contains 2 copies of Pfam domain PF05014 (Nucleoside 2-deoxyribosyltransferase) in Nucleoside deoxyribosyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR007710
Domain description: Nucleoside 2-deoxyribosyltransferase
Occurring in:
  1. Nucleoside deoxyribosyltransferase

Structure domain

CATH CATH domain
3.40.50.450
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Nucleoside deoxyribosyltransferase
The deposited structure of PDB entry 1f8y contains 2 copies of CATH domain 3.40.50.450 (Rossmann fold) in Nucleoside deoxyribosyltransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
52310
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: N-(deoxy)ribosyltransferase-like
Occurring in:
  1. Nucleoside deoxyribosyltransferase
The deposited structure of PDB entry 1f8y contains 2 copies of SCOP domain 52310 (N-deoxyribosyltransferase) in Nucleoside deoxyribosyltransferase. Showing 1 copy in chain A.

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