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Crystal structure of the human acyl protein thioesterase 1 at 1.5 A resolution

Source organism: Homo sapiens
Biochemical function: carboxylic ester hydrolase activity
Biological process: negative regulation of aggrephagy
Cellular component: extracellular exosome

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EC 3.1.2.22: Palmitoyl-(protein) hydrolase

Reaction catalysed:
Palmitoyl-[protein] + H(2)O = palmitate + [protein]
Systematic name:
Palmitoyl-(protein) hydrolase
Alternative Name(s):
  • Palmitoyl-(protein) hydrolase
  • Palmitoyl-protein thioesterase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02230
Domain description: Phospholipase/Carboxylesterase
Occurring in:
  1. Acyl-protein thioesterase 1
The deposited structure of PDB entry 1fj2 contains 2 copies of Pfam domain PF02230 (Phospholipase/Carboxylesterase) in Acyl-protein thioesterase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Acyl-protein thioesterase 1
IPR003140
Domain description: Phospholipase/carboxylesterase/thioesterase
Occurring in:
  1. Acyl-protein thioesterase 1

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Acyl-protein thioesterase 1
The deposited structure of PDB entry 1fj2 contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Acyl-protein thioesterase 1. Showing 1 copy in chain A.
SCOP SCOP annotation
53547
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Acyl-protein thioesterase 1
The deposited structure of PDB entry 1fj2 contains 2 copies of SCOP domain 53547 (Carboxylesterase/thioesterase 1) in Acyl-protein thioesterase 1. Showing 1 copy in chain A.

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