› 1fkd

X-ray diffraction
1.72Å resolution

FK-506 BINDING PROTEIN: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX WITH THE ANTAGONIST L-685,818

Released:
DOI: 10.2210/pdb1fkd/pdb
PDB entry 1fkd coloured by chain, front view.
PDB entry 1fkd coloured by chain, side view.
PDB entry 1fkd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.
Becker JW, Rotonda J, McKeever BM, Chan HK, Marcy AI, Wiederrecht G, Hermes JD, Springer JP
J Biol Chem 268 11335-9 (1993)
PMID: 7684380

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand 818 1 x 818
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P42212
Unit cell:
a: 58.14Å b: 58.14Å c: 55.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 not available not available
Expression system: Not provided

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Citations

6 review citations

Neuroimmunophilins: novel neuroprotective and neuroregenerative targets.
Guo et al. (2001)
5 more

3 mentions without citation

Probing the protein-folding mechanism using denaturant and temperature effects on rate constants.
Guinn et al. (2013)
2 more