› 1fto

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION

Released:
DOI: 10.2210/pdb1fto/pdb
PDB entry 1fto coloured by chain, front view.
PDB entry 1fto coloured by chain, side view.
PDB entry 1fto coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Armstrong N, Gouaux E
Neuron 28 165-81 (2000)
PMID: 11086992

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 62.17Å b: 91.55Å c: 98.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.271 0.224 0.287
Expression system: Escherichia coli

Quick links

Citations

101 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
100 more

45 mentions without citation

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
44 more