› 1fu1

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF HUMAN XRCC4

Released:
DOI: 10.2210/pdb1fu1/pdb
PDB entry 1fu1 coloured by chain, front view.
PDB entry 1fu1 coloured by chain, side view.
PDB entry 1fu1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.
Junop MS, Modesti M, Guarné A, Ghirlando R, Gellert M, Yang W
EMBO J 19 5962-70 (2000)
PMID: 11080143

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-556134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA repair protein XRCC4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13426 (Residues: 1-203; Coverage: 60%)
Gene name: XRCC4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ACY 4 x ACY
1 modified residue:
Ligand CAS 8 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: C2
Unit cell:
a: 164.892Å b: 74.793Å c: 87.307Å
α: 90° β: 103.97° γ: 90°
R-values:
R R work R free
0.246 0.231 0.263
Expression system: Escherichia coli

Quick links

Citations

37 review citations

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
Lieber MR. (2010)
36 more

16 mentions without citation

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.
Junop et al. (2000)
15 more