1fx2

X-ray diffraction
1.46Å resolution

STRUCTURAL ANALYSIS OF ADENYLATE CYCLASES FROM TRYPANOSOMA BRUCEI IN THEIR MONOMERIC STATE

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-572986 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type adenylate cyclase GRESAG 4.1 Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 26.5 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99279 (Residues: 888-1122; Coverage: 19%)
Gene name: GRESAG 4.1
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Nucleotide cyclase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P212121
Unit cell:
a: 49.6Å b: 60.07Å c: 78.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 0.205
Expression system: Escherichia coli