› 1fyv

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1

Released:
DOI: 10.2210/pdb1fyv/pdb
PDB entry 1fyv coloured by chain, front view.
PDB entry 1fyv coloured by chain, side view.
PDB entry 1fyv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L
Nature 408 111-5 (2000)
PMID: 11081518

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172278 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 19.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15399 (Residues: 625-785; Coverage: 21%)
Gene names: KIAA0012, TLR1
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P6422
Unit cell:
a: 101.3Å b: 101.3Å c: 137.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.254 0.296
Expression system: Escherichia coli

Quick links

Citations

100 review citations

Toll-like receptor signalling.
Akira et al. (2004)
99 more

36 mentions without citation

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
35 more