› 1g5n

X-ray diffraction
1.9Å resolution

ANNEXIN V COMPLEX WITH HEPARIN OLIGOSACCHARIDES

Released:
DOI: 10.2210/pdb1g5n/pdb
PDB entry 1g5n coloured by chain, front view.
PDB entry 1g5n coloured by chain, side view.
PDB entry 1g5n coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Capila I, Hernáiz MJ, Mo YD, Mealy TR, Campos B, Dedman JR, Linhardt RJ, Seaton BA
Structure 9 57-64 (2001)
PMID: 11342135

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Annexin A5 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.66 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P14668 (Residues: 2-319; Coverage: 100%)
Gene names: Anx5, Anxa5
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, IDS, UAP
Carbohydrate polymer
1 bound ligand:
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: R3
Unit cell:
a: 155.874Å b: 155.874Å c: 37.344Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.208 0.238
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Heparin-protein interactions.
Capila et al. (2002)
19 more

6 mentions without citation

Sequence and structural features of carbohydrate binding in proteins and assessment of predictability using a neural network.
Malik et al. (2007)
5 more