› 1gc6

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE

Released:
DOI: 10.2210/pdb1gc6/pdb
PDB entry 1gc6 coloured by chain, front view.
PDB entry 1gc6 coloured by chain, side view.
PDB entry 1gc6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T
EMBO J 19 4449-62 (2000)
PMID: 10970839

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-541170 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Radixin Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 35.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26043 (Residues: 1-297; Coverage: 51%)
Gene name: Rdx
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand I3P 1 x I3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-C
Spacegroup: P41212
Unit cell:
a: 96.8Å b: 96.8Å c: 132.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.283
Expression system: Escherichia coli

Quick links

Citations

68 review citations

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Heinrich et al. (2003)
67 more

20 mentions without citation

Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.
Michie et al. (2019)
19 more