› 1gp7

X-ray diffraction
2.6Å resolution

Acidic Phospholipase A2 from venom of Ophiophagus Hannah

Released:
DOI: 10.2210/pdb1gp7/pdb
PDB entry 1gp7 coloured by chain, front view.
PDB entry 1gp7 coloured by chain, side view.
PDB entry 1gp7 coloured by chain, top view.
Source organism: Ophiophagus hannah
Primary publication:
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop".
Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ
J Struct Biol 138 207-15 (2002)
PMID: 12217659

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160466 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 151 amino acids
Theoretical weight: 16.46 KDa
Source organism: Ophiophagus hannah
UniProt:
  • Canonical: P80966 (Residues: 1-151; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 117.92Å b: 62.94Å c: 57.16Å
α: 90° β: 100.93° γ: 90°
R-values:
R R work R free
0.205 0.205 0.233

Quick links

Citations

2 review citations

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase.
Hiu et al. (2020)
1 more

1 mention without citation

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.
Rouault et al. (2006)