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Crystal Structure of Eosinophil Cationic Protein in Complex with 2',5'-ADP at 2.0 A resolution Reveals the Details of the Ribonucleolytic Active site

Source organism: Homo sapiens
Biochemical function: RNA nuclease activity
Biological process: antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular component: azurophil granule lumen

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00074
Domain description: Pancreatic ribonuclease
Occurring in:
  1. Eosinophil cationic protein
The deposited structure of PDB entry 1h1h contains 1 copy of Pfam domain PF00074 (Pancreatic ribonuclease) in Eosinophil cationic protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001427
Domain description: Pancreatic ribonuclease
Occurring in:
  1. Eosinophil cationic protein
IPR023412
Domain description: Ribonuclease A-domain
Occurring in:
  1. Eosinophil cationic protein
IPR036816
Domain description: Ribonuclease A-like domain superfamily
Occurring in:
  1. Eosinophil cationic protein
IPR023411
Domain description: Ribonuclease A, active site
Occurring in:
  1. Eosinophil cationic protein

Structure domain

CATH CATH domain
3.10.130.10
Class: Alpha Beta
Architecture: Roll
Topology: P-30 Protein
Homology: Ribonuclease A-like domain
Occurring in:
  1. Eosinophil cationic protein
The deposited structure of PDB entry 1h1h contains 1 copy of CATH domain 3.10.130.10 (P-30 Protein) in Eosinophil cationic protein. Showing 1 copy in chain A.
SCOP SCOP annotation
54077
Class: Alpha and beta proteins (a+b)
Fold: RNase A-like
Superfamily: RNase A-like
Occurring in:
  1. Eosinophil cationic protein
The deposited structure of PDB entry 1h1h contains 1 copy of SCOP domain 54077 (Ribonuclease A-like) in Eosinophil cationic protein. Showing 1 copy in chain A.

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