› 1haa

Solution NMR

A beta-Hairpin Structure in a 13-mer Peptide that Binds a-Bungarotoxin with High Affinity and Neutralizes its Toxicity

Released:
DOI: 10.2210/pdb1haa/pdb
PDB entry 1haa coloured by chain, front view.
PDB entry 1haa coloured by chain, side view.
PDB entry 1haa coloured by chain, top view.
Source organisms:
Primary publication:
A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity.
Scherf T, Kasher R, Balass M, Fridkin M, Fuchs S, Katchalski-Katzir E
Proc Natl Acad Sci U S A 98 6629-34 (2001)
PMID: 11381118

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158062 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-bungarotoxin Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.01 KDa
Source organism: Bungarus multicinctus
UniProt:
  • Canonical: P60615 (Residues: 22-95; Coverage: 100%)
Sequence domains: Snake toxin cobra-type
Structure domains: CD59
PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.71 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, DYNAMICAL SIMULATED ANNEALING
Expression system: Not provided

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Citations

6 review citations

Exploring protein-protein interactions with phage display.
Sidhu et al. (2003)
5 more

3 mentions without citation

A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity.
Scherf et al. (2001)
2 more