› 1hct

Solution NMR

NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX

Released:
DOI: 10.2210/pdb1hct/pdb
PDB entry 1hct coloured by chain, ensemble of 23 models, front view.
PDB entry 1hct coloured by chain, ensemble of 23 models, side view.
PDB entry 1hct coloured by chain, ensemble of 23 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Xu RX, Word JM, Davis DG, Rink MJ, Willard DH, Gampe RT
Biochemistry 34 2107-21 (1995)
PMID: 7532003

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-537057 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ACETYL-PYEEIE-OH Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 788 Da
Source organism: Homo sapiens
Expression system: Not provided
Proto-oncogene tyrosine-protein kinase Src Chain: B
Molecule details ›
Chain: B
Length: 107 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P12931 (Residues: 144-249; Coverage: 20%)
Gene names: SRC, SRC1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Not provided
  • Escherichia coli BL21

Quick links

Citations

6 review citations

Modular peptide recognition domains in eukaryotic signaling.
Kuriyan et al. (1997)
5 more

2 mentions without citation

Rosmarinic acid, active component of Dansam-Eum attenuates ototoxicity of cochlear hair cells through blockage of caspase-1 activity.
Jeong et al. (2011)
1 more