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REFINED STRUCTURES AT 2 ANGSTROMS AND 2.2 ANGSTROMS OF THE TWO FORMS OF THE H-PROTEIN, A LIPOAMIDE-CONTAINING PROTEIN OF THE GLYCINE DECARBOXYLASE

Source organism: Pisum sativum
Biochemical function: not assigned
Biological process: glycine decarboxylation via glycine cleavage system
Cellular component: glycine cleavage complex

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EC 1.4.4.2: Glycine dehydrogenase (aminomethyl-transferring)

Reaction catalysed:
Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO(2)
Systematic name:
Glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
Alternative Name(s):
  • Glycine cleavage system P-protein
  • Glycine decarboxylase
  • Glycine dehydrogenase (decarboxylating)
  • Glycine-cleavage complex
  • Glycine-cleavage complex P-protein
  • Glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
  • P-protein
  • Protein P1

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF01597
Domain description: Glycine cleavage H-protein
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
The deposited structure of PDB entry 1hpc contains 2 copies of Pfam domain PF01597 (Glycine cleavage H-protein) in Glycine cleavage system H protein, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR033753
Domain description: Glycine cleavage system H-protein/Simiate
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
IPR002930
Domain description: Glycine cleavage system H-protein
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
IPR003016
Domain description: 2-oxo acid dehydrogenase, lipoyl-binding site
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
IPR000089
Domain description: Biotin/lipoyl attachment
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
IPR017453
Domain description: Glycine cleavage system H-protein, subgroup
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
IPR011053
Domain description: Single hybrid motif
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial

Structure domain

CATH CATH domain
2.40.50.100
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
The deposited structure of PDB entry 1hpc contains 2 copies of CATH domain 2.40.50.100 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Glycine cleavage system H protein, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
51231
Class: All beta proteins
Fold: Barrel-sandwich hybrid
Superfamily: Single hybrid motif
Occurring in:
  1. Glycine cleavage system H protein, mitochondrial
The deposited structure of PDB entry 1hpc contains 2 copies of SCOP domain 51231 (Biotinyl/lipoyl-carrier proteins and domains) in Glycine cleavage system H protein, mitochondrial. Showing 1 copy in chain A.

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