› 1hth

Solution NMR

The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures

Released:
DOI: 10.2210/pdb1hth/pdb
PDB entry 1hth coloured by chain, ensemble of 10 models, front view.
PDB entry 1hth coloured by chain, ensemble of 10 models, side view.
PDB entry 1hth coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution.
Weidler M, Marx UC, Seidel G, Schäfer W, Hoffmann E, Esswein A, Rösch P
FEBS Lett 444 239-44 (1999)
PMID: 10050767

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134141 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parathyroid hormone Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 4.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01270 (Residues: 32-65; Coverage: 38%)
Gene name: PTH
Sequence domains: Parathyroid hormone family

Ligands and Environments

No bound ligands
2 modified residues:
Ligand NLE 2 x NLE
Ligand ORN 1 x ORN

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

4 review citations

Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl- terminal ligands.
Murray et al. (2005)
3 more

1 mention without citation

Computing the protein binding sites.
Guo et al. (2012)