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1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN

Source organism: Homo sapiens
Biochemical function: cytokine receptor activity
Biological process: cell surface receptor signaling pathway via STAT
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00041
Domain description: Fibronectin type III domain
Occurring in:
  1. Growth hormone-binding protein
The deposited structure of PDB entry 1hwg contains 2 copies of Pfam domain PF00041 (Fibronectin type III domain) in Growth hormone-binding protein. Showing 1 copy in chain B.

PF09067
Domain description: Erythropoietin receptor, ligand binding
Occurring in:
  1. Growth hormone-binding protein
The deposited structure of PDB entry 1hwg contains 2 copies of Pfam domain PF09067 (Erythropoietin receptor, ligand binding) in Growth hormone-binding protein. Showing 1 copy in chain B.

PF00103
Domain description: Somatotropin hormone family
Occurring in:
  1. Somatotropin
The deposited structure of PDB entry 1hwg contains 1 copy of Pfam domain PF00103 (Somatotropin hormone family) in Somatotropin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Growth hormone-binding protein
IPR001400
Domain description: Somatotropin/prolactin
Occurring in:
  1. Somatotropin
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Growth hormone-binding protein
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Growth hormone-binding protein
IPR003528
Domain description: Long hematopoietin receptor, single chain, conserved site
Occurring in:
  1. Growth hormone-binding protein
IPR015152
Domain description: Growth hormone/erythropoietin receptor, ligand binding
Occurring in:
  1. Growth hormone-binding protein
IPR018116
Domain description: Somatotropin hormone, conserved site
Occurring in:
  1. Somatotropin
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Somatotropin
IPR034975
Domain description: Somatotropin
Occurring in:
  1. Somatotropin

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Growth hormone-binding protein
The deposited structure of PDB entry 1hwg contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Growth hormone-binding protein. Showing 2 copies in chain B.
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Somatotropin
The deposited structure of PDB entry 1hwg contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Somatotropin. Showing 1 copy in chain A.
SCOP SCOP annotations
49266
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Fibronectin type III
Occurring in:
  1. Growth hormone-binding protein
The deposited structure of PDB entry 1hwg contains 4 copies of SCOP domain 49266 (Fibronectin type III) in Growth hormone-binding protein. Showing 2 copies in chain B.
47267
Class: All alpha proteins
Fold: 4-helical cytokines
Superfamily: 4-helical cytokines
Occurring in:
  1. Somatotropin
The deposited structure of PDB entry 1hwg contains 1 copy of SCOP domain 47267 (Long-chain cytokines) in Somatotropin. Showing 1 copy in chain A.

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