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CRYSTAL STRUCTURE OF TEAS W273S FORM 1

Source organism: Nicotiana tabacum
Biochemical function: 5-epi-aristolochene synthase activity
Biological process: sesquiterpene biosynthetic process
Cellular component: cytoplasm

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EC 4.2.3.61: 5-epiaristolochene synthase

Reaction catalysed:
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-5-epiaristolochene-forming)
Alternative Name(s):
  • 5-epi-aristolochene synthase
  • EAS
  • Farnesyl pyrophosphate cyclase
  • TEAS
  • Tobacco epiaristolochene synthase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03936
Domain description: Terpene synthase family, metal binding domain
Occurring in:
  1. 5-epi-aristolochene synthase
The deposited structure of PDB entry 1hx9 contains 1 copy of Pfam domain PF03936 (Terpene synthase family, metal binding domain) in 5-epi-aristolochene synthase. Showing 1 copy in chain A.

PF01397
Domain description: Terpene synthase, N-terminal domain
Occurring in:
  1. 5-epi-aristolochene synthase
The deposited structure of PDB entry 1hx9 contains 1 copy of Pfam domain PF01397 (Terpene synthase, N-terminal domain) in 5-epi-aristolochene synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. 5-epi-aristolochene synthase
IPR005630
Domain description: Terpene synthase, metal-binding domain
Occurring in:
  1. 5-epi-aristolochene synthase
IPR036965
Domain description: Terpene synthase, N-terminal domain superfamily
Occurring in:
  1. 5-epi-aristolochene synthase
IPR001906
Domain description: Terpene synthase, N-terminal domain
Occurring in:
  1. 5-epi-aristolochene synthase
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. 5-epi-aristolochene synthase
IPR044814
Domain description: Terpene cyclases, class 1, plant
Occurring in:
  1. 5-epi-aristolochene synthase

Structure domains

CATH CATH domains
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. 5-epi-aristolochene synthase
The deposited structure of PDB entry 1hx9 contains 1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in 5-epi-aristolochene synthase. Showing 1 copy in chain A.
1.50.10.130
Class: Mainly Alpha
Architecture: Alpha/alpha barrel
Topology: Glycosyltransferase
Homology: Terpene synthase, N-terminal domain
Occurring in:
  1. 5-epi-aristolochene synthase
The deposited structure of PDB entry 1hx9 contains 1 copy of CATH domain 1.50.10.130 (Glycosyltransferase) in 5-epi-aristolochene synthase. Showing 1 copy in chain A.
SCOP SCOP annotations
48583
Class: All alpha proteins
Fold: Terpenoid synthases
Superfamily: Terpenoid synthases
Occurring in:
  1. 5-epi-aristolochene synthase
The deposited structure of PDB entry 1hx9 contains 1 copy of SCOP domain 48583 (Terpenoid cyclase C-terminal domain) in 5-epi-aristolochene synthase. Showing 1 copy in chain A.
48240
Class: All alpha proteins
Fold: alpha/alpha toroid
Superfamily: Terpenoid cyclases/Protein prenyltransferases
Occurring in:
  1. 5-epi-aristolochene synthase
The deposited structure of PDB entry 1hx9 contains 1 copy of SCOP domain 48240 (Terpenoid cyclase N-terminal domain) in 5-epi-aristolochene synthase. Showing 1 copy in chain A.

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