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CRYSTAL STRUCTURE OF HUMAN AUH PROTEIN, AN RNA-BINDING HOMOLOGUE OF ENOYL-COA HYDRATASE

Source organism: Homo sapiens
Biochemical function: catalytic activity
Biological process: not assigned
Cellular component: not assigned

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EC 4.2.1.56: Itaconyl-CoA hydratase

Reaction catalysed:
Citramalyl-CoA = itaconyl-CoA + H(2)O
Systematic name:
Citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
Alternative Name(s):
  • Citramalyl-CoA hydro-lyase
  • Itaconyl coenzyme A hydratase

EC 4.2.1.18: Methylglutaconyl-CoA hydratase

Reaction catalysed:
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O
Systematic name:
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
Alternative Name(s):
  • (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase
  • 3-methylglutaconyl CoA hydratase
  • Methylglutaconase
  • Methylglutaconyl coenzyme A hydratase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00378
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
The deposited structure of PDB entry 1hzd contains 6 copies of Pfam domain PF00378 (Enoyl-CoA hydratase/isomerase) in Methylglutaconyl-CoA hydratase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014748
Domain description: Enoyl-CoA hydratase, C-terminal
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
IPR018376
Domain description: Enoyl-CoA hydratase/isomerase, conserved site
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
IPR001753
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial

Structure domains

CATH CATH domains
1.10.12.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Lyase 2-enoyl-coa Hydratase; Chain A, domain 2
Homology: Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
The deposited structure of PDB entry 1hzd contains 6 copies of CATH domain 1.10.12.10 (Lyase 2-enoyl-coa Hydratase; Chain A, domain 2) in Methylglutaconyl-CoA hydratase, mitochondrial. Showing 1 copy in chain A.
3.90.226.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Homology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
The deposited structure of PDB entry 1hzd contains 6 copies of CATH domain 3.90.226.10 (2-enoyl-CoA Hydratase; Chain A, domain 1) in Methylglutaconyl-CoA hydratase, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
52103
Class: Alpha and beta proteins (a/b)
Fold: ClpP/crotonase
Superfamily: ClpP/crotonase
Occurring in:
  1. Methylglutaconyl-CoA hydratase, mitochondrial
The deposited structure of PDB entry 1hzd contains 6 copies of SCOP domain 52103 (Crotonase-like) in Methylglutaconyl-CoA hydratase, mitochondrial. Showing 1 copy in chain A.

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