› 1i7g

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ 242

Released:
DOI: 10.2210/pdb1i7g/pdb
PDB entry 1i7g coloured by chain, front view.
PDB entry 1i7g coloured by chain, side view.
PDB entry 1i7g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
Cronet P, Petersen JF, Folmer R, Blomberg N, Sjöblom K, Karlsson U, Lindstedt EL, Bamberg K
Structure 9 699-706 (2001)
PMID: 11587644

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07869 (Residues: 196-468; Coverage: 58%)
Gene names: NR1C1, PPAR, PPARA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand AZ2 1 x AZ2
Ligand CPQ 1 x CPQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 76.968Å b: 76.968Å c: 100.592Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.237 0.271
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.
Lefebvre et al. (2006)
30 more

27 mentions without citation

The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development.
Hong et al. (2018)
26 more