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CHALCONE SYNTHASE, G256A MUTANT

Source organism: Medicago sativa
Biochemical function: acyltransferase activity, transferring groups other than amino-acyl groups
Biological process: polyketide biosynthetic process
Cellular component: not assigned

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EC 2.3.1.74: Chalcone synthase

Reaction catalysed:
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2)
Systematic name:
Malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Alternative Name(s):
  • 6'-deoxychalcone synthase
  • CHS
  • Chalcone synthetase
  • DOCS
  • Flavanone synthase
  • Flavonone synthase
  • Naringenin-chalcone synthase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02797
Domain description: Chalcone and stilbene synthases, C-terminal domain
Occurring in:
  1. Chalcone synthase 2
The deposited structure of PDB entry 1i86 contains 1 copy of Pfam domain PF02797 (Chalcone and stilbene synthases, C-terminal domain) in Chalcone synthase 2. Showing 1 copy in chain A.

PF00195
Domain description: Chalcone and stilbene synthases, N-terminal domain
Occurring in:
  1. Chalcone synthase 2
The deposited structure of PDB entry 1i86 contains 1 copy of Pfam domain PF00195 (Chalcone and stilbene synthases, N-terminal domain) in Chalcone synthase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. Chalcone synthase 2
IPR011141
Domain description: Polyketide synthase, type III
Occurring in:
  1. Chalcone synthase 2
IPR012328
Domain description: Chalcone/stilbene synthase, C-terminal
Occurring in:
  1. Chalcone synthase 2
IPR018088
Domain description: Chalcone/stilbene synthase, active site
Occurring in:
  1. Chalcone synthase 2
IPR001099
Domain description: Chalcone/stilbene synthase, N-terminal
Occurring in:
  1. Chalcone synthase 2

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. Chalcone synthase 2
The deposited structure of PDB entry 1i86 contains 2 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in Chalcone synthase 2. Showing 2 copies in chain A.
SCOP SCOP annotation
53914
Class: Alpha and beta proteins (a/b)
Fold: Thiolase-like
Superfamily: Thiolase-like
Occurring in:
  1. Chalcone synthase 2
The deposited structure of PDB entry 1i86 contains 2 copies of SCOP domain 53914 (Chalcone synthase-like) in Chalcone synthase 2. Showing 2 copies in chain A.

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