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CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD32A99A)-HEN LYSOZYME COMPLEX

Source organisms:
Biochemical function: identical protein binding
Biological process: adaptive immune response
Cellular component: immunoglobulin complex

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EC 3.2.1.17: Lysozyme

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Systematic name:
Peptidoglycan N-acetylmuramoylhydrolase
Alternative Name(s):
  • 1,4-N-acetylmuramidase
  • Globulin G
  • Globulin G1
  • L-7001
  • Lysozyme g
  • Mucopeptide N-acetylmuramoylhydrolase
  • Mucopeptide glucohydrolase
  • Muramidase
  • N,O-diacetylmuramidase
  • PR1-lysozyme

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
The deposited structure of PDB entry 1ic7 contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig kappa chain V-V region L7. Showing 1 copy in chain A [auth L].
The deposited structure of PDB entry 1ic7 contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig heavy chain V region 36-60. Showing 1 copy in chain B [auth H].

PF00062
Domain description: C-type lysozyme/alpha-lactalbumin family
Occurring in:
  1. Lysozyme C
The deposited structure of PDB entry 1ic7 contains 1 copy of Pfam domain PF00062 (C-type lysozyme/alpha-lactalbumin family) in Lysozyme C. Showing 1 copy in chain C [auth Y].

InterPro InterPro annotations
IPR001916
Domain description: Glycoside hydrolase, family 22
Occurring in:
  1. Lysozyme C
IPR000974
Domain description: Glycoside hydrolase, family 22, lysozyme
Occurring in:
  1. Lysozyme C
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
IPR019799
Domain description: Glycoside hydrolase family 22 domain
Occurring in:
  1. Lysozyme C
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. Lysozyme C
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. Immunoglobulin kappa variable 5-48

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
The deposited structure of PDB entry 1ic7 contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig kappa chain V-V region L7. Showing 1 copy in chain A [auth L].
The deposited structure of PDB entry 1ic7 contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig heavy chain V region 36-60. Showing 1 copy in chain B [auth H].
1.10.530.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Lysozyme
Homology: Lysozyme
Occurring in:
  1. Lysozyme C
The deposited structure of PDB entry 1ic7 contains 1 copy of CATH domain 1.10.530.10 (Lysozyme) in Lysozyme C. Showing 1 copy in chain C [auth Y].
SCOP SCOP annotations
48727
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. Ig heavy chain V region 36-60
  2. Immunoglobulin kappa variable 5-48
The deposited structure of PDB entry 1ic7 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Ig kappa chain V-V region L7. Showing 1 copy in chain A [auth L].
The deposited structure of PDB entry 1ic7 contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Ig heavy chain V region 36-60. Showing 1 copy in chain B [auth H].
53960
Class: Alpha and beta proteins (a+b)
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Occurring in:
  1. Lysozyme C
The deposited structure of PDB entry 1ic7 contains 1 copy of SCOP domain 53960 (C-type lysozyme) in Lysozyme C. Showing 1 copy in chain C [auth Y].

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