EC 1.1.1.42: Isocitrate dehydrogenase (NADP(+))
Reaction catalysed:
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Systematic name:
Isocitrate:NADP(+) oxidoreductase (decarboxylating)
Alternative Name(s):
- Dual-cofactor-specific isocitrate dehydrogenase
- IDH
- IDP
- IDP1
- IDP2
- IDP3
- Isocitrate (NADP) dehydrogenase
- Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
- Isocitrate dehydrogenase (NADP)
- Isocitrate dehydrogenase (NADP-dependent)
- NADP isocitric dehydrogenase
- NADP(+)-ICDH
- NADP(+)-IDH
- NADP(+)-linked isocitrate dehydrogenase
- NADP-dependent isocitrate dehydrogenase
- NADP-dependent isocitric dehydrogenase
- NADP-linked isocitrate dehydrogenase
- NADP-specific isocitrate dehydrogenase
- Oxalosuccinate decarboxylase
- Oxalsuccinic decarboxylase
- Triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase
Protein family (Pfam)![The deposited structure of PDB entry 1ide contains 1 copy of Pfam domain PF00180 (Isocitrate/isopropylmalate dehydrogenase) in Isocitrate dehydrogenase [NADP]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1ide_1_A_Pfam_PF00180_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ide</span> contains 1 copy of Pfam domain <span class='highlight'>PF00180 (Isocitrate/isopropylmalate dehydrogenase)</span> in <span class='highlight'>Isocitrate dehydrogenase [NADP]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 1ide contains 1 copy of CATH domain 3.40.718.10 (Isopropylmalate Dehydrogenase) in Isocitrate dehydrogenase [NADP]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1ide_1_A_CATH_3.40.718.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ide</span> contains 1 copy of CATH domain <span class='highlight'>3.40.718.10 (Isopropylmalate Dehydrogenase)</span> in <span class='highlight'>Isocitrate dehydrogenase [NADP]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
SCOP annotation![The deposited structure of PDB entry 1ide contains 1 copy of SCOP domain 53660 (Dimeric isocitrate & isopropylmalate dehydrogenases) in Isocitrate dehydrogenase [NADP]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1ide_1_A_SCOP_53660_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ide</span> contains 1 copy of SCOP domain <span class='highlight'>53660 (Dimeric isocitrate & isopropylmalate dehydrogenases)</span> in <span class='highlight'>Isocitrate dehydrogenase [NADP]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")