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CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2

X-ray diffraction
2.3Å resolution
PDB entry 1iil coloured by chain, front view.
PDB entry 1iil coloured by chain, side view.
PDB entry 1iil coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor receptor 2 and Fibroblast growth factor 2
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Multimeric state: hetero dimer
Accessible surface area: 15683.11 Å2
Buried surface area: 3063.39 Å2
Dissociation area: 1,531.7 Å2
Dissociation energy (ΔGdiss): 10.46 kcal/mol
Dissociation entropy (TΔSdiss): 12.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140534
Assembly 2
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Assembly Name: Fibroblast growth factor receptor 2 and Fibroblast growth factor 2
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Multimeric state: hetero dimer
Accessible surface area: 15608.87 Å2
Buried surface area: 3076.28 Å2
Dissociation area: 1,538.14 Å2
Dissociation energy (ΔGdiss): 8.62 kcal/mol
Dissociation entropy (TΔSdiss): 12.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140534
Assembly 3
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Assembly Name: Fibroblast growth factor receptor 2 and Fibroblast growth factor 2
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Multimeric state: hetero dimer
Accessible surface area: 16872.88 Å2
Buried surface area: 2846.14 Å2
Dissociation area: 1,423.07 Å2
Dissociation energy (ΔGdiss): 6.78 kcal/mol
Dissociation entropy (TΔSdiss): 12.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140534
Assembly 4
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Assembly Name: Fibroblast growth factor receptor 2 and Fibroblast growth factor 2
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Multimeric state: hetero dimer
Accessible surface area: 16755.92 Å2
Buried surface area: 2929.56 Å2
Dissociation area: 1,464.78 Å2
Dissociation energy (ΔGdiss): 6.04 kcal/mol
Dissociation entropy (TΔSdiss): 12.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140534

Macromolecules

Fibroblast growth factor 2
Chains: A, B, C, D
Length: 155 amino acids
Theoretical weight: 17.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09038 (Residues: 134-288; Coverage: 54%)
Gene names: FGF2, FGFB
Pfam: Fibroblast growth factor
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
SCOP: Fibroblast growth factors (FGF)
Fibroblast growth factor 2 in PDB entry 1iil, assembly 1, front view.
Fibroblast growth factor 2 in PDB entry 1iil, assembly 1, side view.
Fibroblast growth factor 2 in PDB entry 1iil, assembly 1, top view.
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Fibroblast growth factor receptor 2
Chains: E, F, G, H
Length: 220 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21802 (Residues: 147-366; Coverage: 28%)
Gene names: BEK, FGFR2, KGFR, KSAM
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: I set domains
Fibroblast growth factor receptor 2 in PDB entry 1iil, assembly 1, front view.
Fibroblast growth factor receptor 2 in PDB entry 1iil, assembly 1, side view.
Fibroblast growth factor receptor 2 in PDB entry 1iil, assembly 1, top view.
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