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STRUCTURAL ANALYSIS OF INOSITOL MONOPHOSPHATASE COMPLEXES WITH SUBSTRATES

X-ray diffraction
2.2Å resolution
PDB entry 1imb coloured by chain, front view.
PDB entry 1imb coloured by chain, side view.
PDB entry 1imb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inositol monophosphatase 1
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Multimeric state: homo dimer
Accessible surface area: 20888.42 Å2
Buried surface area: 4828.01 Å2
Dissociation area: 1,648.72 Å2
Dissociation energy (ΔGdiss): 15.54 kcal/mol
Dissociation entropy (TΔSdiss): 13.42 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151370

Macromolecules

Inositol monophosphatase 1
Chains: A, B
Length: 277 amino acids
Theoretical weight: 30.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29218 (Residues: 1-277; Coverage: 100%)
Gene names: IMPA, IMPA1
Pfam: Inositol monophosphatase family
InterPro:
CATH:
SCOP: Inositol monophosphatase/fructose-1,6-bisphosphatase-like
Inositol monophosphatase 1 in PDB entry 1imb, assembly 1, front view.
Inositol monophosphatase 1 in PDB entry 1imb, assembly 1, side view.
Inositol monophosphatase 1 in PDB entry 1imb, assembly 1, top view.
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