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NMR STRUCTURE OF HUMAN DNA LIGASE IIIALPHA BRCT DOMAIN

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 6.5.1.1: DNA ligase (ATP)

Reaction catalysed:
(1a) ATP + [DNA ligase]-L-lysine = [DNA ligase]-N(6)-(5'-adenylyl)-L-lysine + diphosphate
Systematic name:
Poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP)
Alternative Name(s):
  • DNA joinase
  • DNA ligase
  • DNA repair enzyme
  • DNA-joining enzyme
  • Deoxyribonucleate ligase
  • Deoxyribonucleic acid joinase
  • Deoxyribonucleic acid ligase
  • Deoxyribonucleic acid repair enzyme
  • Deoxyribonucleic acid-joining enzyme
  • Deoxyribonucleic joinase
  • Deoxyribonucleic ligase
  • Deoxyribonucleic repair enzyme
  • Deoxyribonucleic-joining enzyme
  • Poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
  • Polydeoxyribonucleotide synthase (ATP)
  • Polynucleotide ligase
  • Polynucleotide ligase (ATP)
  • Sealase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF16759
Domain description: DNA ligase 3 BRCT domain
Occurring in:
  1. DNA ligase 3
The deposited structure of PDB entry 1imo contains 1 copy of Pfam domain PF16759 (DNA ligase 3 BRCT domain) in DNA ligase 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001357
Domain description: BRCT domain
Occurring in:
  1. DNA ligase 3
IPR036420
Domain description: BRCT domain superfamily
Occurring in:
  1. DNA ligase 3
IPR031916
Domain description: DNA ligase 3, BRCT domain
Occurring in:
  1. DNA ligase 3

Structure domain

CATH CATH domain
3.40.50.10190
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: BRCT domain
Occurring in:
  1. DNA ligase 3
The deposited structure of PDB entry 1imo contains 1 copy of CATH domain 3.40.50.10190 (Rossmann fold) in DNA ligase 3. Showing 1 copy in chain A.
SCOP SCOP annotation
52117
Class: Alpha and beta proteins (a/b)
Fold: BRCT domain
Superfamily: BRCT domain
Occurring in:
  1. DNA ligase 3
The deposited structure of PDB entry 1imo contains 1 copy of SCOP domain 52117 (DNA ligase) in DNA ligase 3. Showing 1 copy in chain A.

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