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Crystal structure of interleukin 10 reveals an interferon gamma-like fold.

Walter MR, Nagabhushan TL
Biochemistry 34 12118-25 (1995)
Cited: 85 times
EuropePMC logo PMID: 7547951

Abstract

The crystal structure of recombinant human interleukin 10 (rhIL-10) has been determined by X-ray crystallography at 2.0 A resolution. Interleukin 10 is a dimer composed of identical polypeptide chains related by a 2-fold axis. The molecule is predominantly alpha-helical. The main-chain fold resembles that of interferon gamma (IFN-gamma) in which the structural integrity of each domain is dependent on the intertwining of helices from each peptide chain. Comparison of rhIL-10 and IFN-gamma reveals differences in helix lengths and orientations of the 2-fold related domains. Interleukin 10 and IFN-gamma contain several conserved residues in their internal cores which suggest a possible "fingerprint" for detection of other members of this fold.

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Related citations provided by authors (1)

  1. Crystallization and Preliminary X-Ray Investigation of Human Interleukin-10. Cook WJ, Windsor WT, Murgola NJ, Tindall SH, Nagabhushan TL, Walter MR Proteins 22 187- (1995)

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