› 1iqg

X-ray diffraction
2.6Å resolution

Human coagulation factor Xa in complex with M55159

Released:
DOI: 10.2210/pdb1iqg/pdb
PDB entry 1iqg coloured by chain, front view.
PDB entry 1iqg coloured by chain, side view.
PDB entry 1iqg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shiromizu I, Matsusue T

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133209 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activated factor Xa heavy chain Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 26.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-469; Coverage: 51%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain Chain: L
Molecule details ›
Chain: L
Length: 96 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 84-179; Coverage: 21%)
Gene name: F10
Sequence domains:
Structure domains: Laminin

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand XME 1 x XME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 72.26Å b: 78.6Å c: 56.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 0.271

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