› 1irg

Solution NMR

INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1irg/pdb
PDB entry 1irg coloured by chain, ensemble of 20 models, front view.
PDB entry 1irg coloured by chain, ensemble of 20 models, side view.
PDB entry 1irg coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family.
Furui J, Uegaki K, Yamazaki T, Shirakawa M, Swindells MB, Harada H, Taniguchi T, Kyogoku Y
Structure 6 491-500 (1998)
PMID: 9562558

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon regulatory factor 2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 13.35 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P23906 (Residues: 2-113; Coverage: 32%)
Gene name: Irf2
Sequence domains: Interferon regulatory factor transcription factor
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Interferon regulatory factors: the next generation.
Mamane et al. (1999)
3 more

2 mentions without citation

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease.
Szelag et al. (2016)
1 more