EC 5.3.1.9: Glucose-6-phosphate isomerase
Reaction catalysed:
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Systematic name:
Alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
Alternative Name(s):
- D-glucose-6-phosphate ketol-isomerase
- Glucose phosphate isomerase
- Hexose monophosphate isomerase
- Hexose phosphate isomerase
- Hexosephosphate isomerase
- Oxoisomerase
- Phosphoglucoisomerase
- Phosphoglucose isomerase
- Phosphohexoisomerase
- Phosphohexomutase
- Phosphohexose isomerase
- Phosphosaccharomutase
GO terms
Biochemical function:
Biological process:
- carbohydrate derivative metabolic process
- GDP-mannose biosynthetic process from glucose
- glucose 6-phosphate metabolic process
- response to cadmium ion
- negative regulation of neuron apoptotic process
- glucose homeostasis
- response to muscle stretch
- response to immobilization stress
- erythrocyte homeostasis
- response to testosterone
- response to progesterone
- response to estradiol
- positive regulation of endothelial cell migration
- learning or memory
- hemostasis
- signal transduction
- humoral immune response
- glycolytic process
- gluconeogenesis
- fructose 6-phosphate metabolic process
- carbohydrate metabolic process
- positive regulation of immunoglobulin production
- mesoderm formation
- in utero embryonic development
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
3.40.50.10490
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
Glucose-6-phosphate isomerase like protein; domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1iri</span> contains 8 copies of CATH domain <span class='highlight'>3.40.50.10490 (Rossmann fold)</span> in <span class='highlight'>Glucose-6-phosphate isomerase</span>. Showing 2 copies in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1iri contains 8 copies of CATH domain 3.40.50.10490 (Rossmann fold) in Glucose-6-phosphate isomerase. Showing 2 copies in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1iri_1_A_CATH_3.40.50.10490_image-200x200.png)